FROM ISRAEL, A NEW HOPE FOR THE TREATMENT OF DEPRESSION

Depression is a complex and widespread mood disorder, characterized not only by persistent sadness and loss of interest, but also by changes in sleep, appetite, concentration and self-esteem.

La depressione è un disturbo dell'umore molto diffuso

It is not simple melancholy, but a true clinical condition that can significantly affect quality of life.

Despite major advances in recent decades, depression treatment is still often based on a “trial and error” approach: a medication is prescribed, weeks are waited, results are evaluated, and therapies are changed if ineffective. This process can lead to long delays, frustration, side effects and, in some cases, loss of trust in treatment.

This is where NeuroKaire, an Israeli precision medicine startup, introduces a promising innovation that is attracting international attention. Its technology begins with a simple blood sample from the patient. Cells are reprogrammed into a stem-cell-like state and then developed into personalized neurons. Different antidepressants are tested directly on these neurons to identify which produces the best response.

In essence, NeuroKaire creates a personalized “mini-brain” on a laboratory plate, allowing clinicians to predict which antidepressant may work best for each individual patient.

This breakthrough is made possible by the integration of cellular biology and artificial intelligence. NeuroKaire’s AI algorithms analyze neuronal behavior and translate complex biological data into clinically useful insights.

While not a miracle cure, this technology aims to reduce treatment time, therapeutic errors and side effects, bringing psychiatry closer to true personalized medicine.

Supported by the European Innovation Council and currently in advanced validation phases, NeuroKaire has the potential to significantly change how depression is treated in the coming years.

Luciano Bassani

Through PortaleCEM, the Jewish Community of Milan highlights this innovation as part of its broader mission to share Israeli scientific excellence and promote high-quality medical and cultural information for the Jewish community in Italy and worldwide.